Nephrotoxicity and Hepatotoxicity Induced by Inhaled Bromodichloromethane in Wild-Type and p53-Heterozygous Mice
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چکیده
منابع مشابه
Induction of micronuclei in wild-type and p53(+/-) transgenic mice by inhaled bromodichloromethane.
Bromodichloromethane (BDCM) is commonly present in trace amounts in drinking water as a disinfection by-product. BDCM has been shown to be carcinogenic in mice and rats when given by gavage at relatively high doses. Genotoxic activity as well as induced regenerative cell proliferation may contribute to the carcinogenic potential of BDCM. The purpose of the current studies was to evaluate the ab...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2001
ISSN: 1096-0929
DOI: 10.1093/toxsci/64.2.269